【个人简历】

2004.09 — 2008.07 北京师范大学化学学院 理学学士

2008.09 — 2014.01 中国科学院化学研究所（保送） 理学博士 导师：王梅祥 院士

2014.02 — 2014.06 康龙化成（北京）新药技术股份有限公司 有机合成高级研究员

2014.07 — 2017.12 新加坡南洋理工大学化学与化学生物学系 Research Fellow 合作导师：Jianrong Steve Zhou

2018.01 — 2020.12 上海大学理学院化学系 特聘研究员

2019.01 — 2023.12 上海大学理学院化学系 副教授

2023.12 — 至今 上海大学理学院化学系 教授（破格）

【研究方向】

近年来，课题组致力于刚性扩展卟啉的创制及性能研究，重点关注这类新型大环分子的光物理性质及手性光学性能。迄今已在国际学术期刊以第一或通讯作者发表论文30余篇，包括J. Am. Chem. Soc. 4篇、Angew. Chem. Int. Ed. 3 篇、Chem. Sci. 3篇等，论文他引900余次。指导的研究生多人次荣获上海大学校长奖学金、研究生国家奖学金、上海市优秀毕业生等荣誉。欢迎对有机化学、超分子化学和材料化学感兴趣的本科生和研究生加入本课题组！

【讲授课程】

本科生课程：《有机化学》、《理论有机化学》、《有机化学实验》、《大学化学实验》

研究生课程：《高等有机化学》、《有机反应机理》

【科研项目】

1. 具有稳定自由基性质的新型扩展卟啉的设计、合成及性能研究，国家自然科学基金面上项目（22171179），主持，2022.01-2025.12

2. 对酸具有响应性的新型扩展卟啉的设计、合成及其在生物医学中的应用研究，上海市“科技创新行动计划”启明星计划（20QA1403700），主持，2020.06-2023.12

3. 具有质子耦合电子转移性质的新型扩展卟啉超分子主体的构建及其合成应用研究，国家自然科学基金青年基金（21901155），主持，2020.01-2022.12

4. 上海市教委青年教师科研专项基金，主持，2020.01-2022.12

5. 上海市高校特聘教授（东方学者）主持，2019.07-2022.08

【代表性论文】

1. Yang, L.; Lei, C.-H.; Wang, D.-X.; Huang, Z.-T.; Wang, M.-X.* Highly Efficient and Expedient Synthesis of 5-Hydroxy-1H-pyrrol-2-(5H)-ones from FeCl₃-Catalyzed Tandem Intramolecular Enaminic Addition of Tertiary Enamides to Ketones and 1,3-Hydroxy Rearrangement. Org. Lett. 2010, 12, 3918-3921.

2. Lei, C.-H.; Wang, D.-X.; Zhao, L.; Zhu, J.; Wang, M.-X.* Synthesis of Substituted Pyridines from Cascade [1+5] Cycloaddition of Isonitriles to N-Formylmethyl-substituted Enamides, Aerobic Oxidative Aromatization, and Acyl Transfer Reaction. J. Am. Chem. Soc. 2013, 135, 4708-4711.

3. Lei, C.-H.; Wang, D.-X.; Zhao, L.; Zhu, J.; Wang, M.-X.* Synthesis of Multifunctionalized 1,2,3,4-Tetrahydropyridines, 2,3-Dihydropyridin-4(1H)-ones and Pyridines from Tandem Reactions Initiated by [5+1] Cycloaddition of N-Formylmethyl-Substituted Enamides to Isocyanides: Mechanistic Insight and Synthetic Application. Chem. Eur. J. 2013, 19, 16981-16987.

4. Lei, C.-H.; Zhao, L.; Wang, D.-X.; Zhu, J.; Wang, M.-X.* Functionalized Imidazoliniums from the Three-component Domino Reaction of N-Formylmethylcarboxamides with Amines and Isocyanides. Org. Chem. Front. 2014, 1, 909-913.

5. Wu, X.; Lei, C.; Yue, G.; Zhou, J. S.* Palladium-Catalyzed Direct Cyclopropylation of Heterocycles. Angew. Chem. Int. Ed. 2015, 54, 9601-9605.

6. Lei, C.; Jin, X.; Zhou, J. S.* Palladium-Catalyzed Heteroarylation and Concomitant ortho-Alkylation of Aryl Iodides. Angew. Chem. Int. Ed. 2015, 54, 13397-13400.

7. Lei, C.; Jin, X.; Zhou, J. S.* Palladium-catalyzed Alkynylation and Concomitant ortho Alkylation of Aryl Iodides. ACS Catalysis 2016, 6, 1635-1639.

8. Lei, C.;^§ Cao, J.;^§ Zhou, J. S.* Palladium-catalyzed Arylation of Ketones and Acetonitrile with ortho-Alkylation of Aryl Rings: de novo Synthesis of Tetralines and Benzocycloheptenes. Org. Lett. 2016, 18, 6120-6123.

9. Lei, C.; Yip, Y. J.; Zhou, J. S.* Nickel-Catalyzed Direct Synthesis of Aryl Olefins from Ketones and Organoboron Reagents under Neutral Conditions. J. Am. Chem. Soc. 2017, 139, 6086-6089.

(After joining in Shanghai University)

10. Xu, X.-M.;^§ Lei, C.-H.;^§ Tong, S.; Zhu, J.; Wang, M.-X.* Lewis Acid Catalyst-steered Divergent Synthesis of Functionalized Vicinal Amino Alcohols and Pyrroles from Tertiary Enamides. Org. Chem. Front. 2018, 5, 3138-3142. (co-first author).

11. Lei, C.; Zhu, D.; Tangcueco, V. I. T.; Zhou, J. S.* Arylation of Aldehydes to Directly Form Ketones via Tandem Nickel Catalysis. Org. Lett. 2019, 21, 5817-5822.

12. Ye, D.; Liu, Z.; Chen, H.; Sessler, J. L.;* Lei, C.* Cesium Carbonate Catalyzed Esterification of N-Benzyl-N-Boc Amides under Ambient Conditions. Org. Lett. 2019, 21, 6888-6892.

13. Wang, F.; Sen, S.; Chen, C.; Bähring, S.;* Lei, C.;* Duan, Z.; Zhang, Z.;* Sessler, J. L.;* Jana, A.* Self-Assembled Cagelike Receptor That Binds Biologically Relevant Dicarboxylic Acids via Proton-Coupled Anion Recognition. J. Am. Chem. Soc. 2020, 142, 1987-1994.

14. Kim, T.; Duan, Z.; Talukdar, S.; Lei, C.;* Kim, D.;* Sessler, J. L.;* Sarma, T.* Excitonically Coupled Cyclic BF₂ Arrays of Calix[8]- and Calix[16]phyrin as Near-IR-Chromophores. Angew. Chem. Int. Ed. 2020, 59, 13063-13070.

15. Ye, D.; Liu, Z.; Sessler, J. L.;* Lei, C.* Base-free oxidation of alcohols enabled by nickel(II)-catalyzed transfer dehydrogenation. Chem. Commun. 2020, 56, 11811-11814.

16. Ye, D.; Chen, H.; Liu, Z.; Lei, C.* Transamidation of N-benzyl-N-Boc Amides under Transition Metal-free and Base-free Conditions. Chin. J. Org. Chem. 2021, 41, 1658-1669.

17. Zhou, W.; Hao, M.; Lu, T.; Duan, Z.; Sarma, T.;* Sessler, J. L.;* Lei, C.* Carbazole-Containing Carbadecaphyrins: Non-aromatic Expanded Porphyrins that Undergo Proton-Triggered Conformational Changes. Chem. Eur. J. 2021, 27, 16173-16180.

18. Zhou, W.; Sarma, T.; Su, Y.; Lei, C.;* Sessler, J. L.* Kinetic trapping of a cobalt(II) metallocage using an carbazole-containing expanded carbaporphyrinoid ligand. Chem. Sci. 2022, 13, 692-697.

19. Zheng, Y.;^§ Wang, X.;^§ Chen, H.; Lu, T.; Duan, Z.; Lei, C.* 1,4-Phenylene-Incorporated Decaphyrin(1.0.1.0.0.1.0.1.0.0): Synthesis, Structure, and Topological Chirality. Org. Lett. 2022, 24, 2509-2514.

20. Chen, H.; Shi, X.; Lun, Y.; Xu, Y.; Lu, T.; Duan, Z.; Shao M.; Sessler, J. L.;^* Yu, H.;^* Lei, C.^* 3,6-Carbazoylene Octaphyrin (1.0.0.0.1.0.0.0) and Its Bis-BF₂ Complex. J. Am. Chem. Soc. 2022, 144, 8194–8203.

21. Zhou, W.; Sarma, T.; Yang, L.; Lei, C.;^* Sessler, J. L.^* Controlled assembly of a bicyclic porphyrinoid and its 3-dimensional boron difluoride arrays. Chem. Sci. 2022, 13, 7276-7282.

22. Liang, K.;^§ Chen, H.;^§ Wang, X.; Lu, T.; Duan, Z.; Sessler, J. L.;* Lei, C.* Di-2,7-pyrenidecaphyrin(1.1.0.0.0.1.1.0.0.0) and Its Bis-Organopalladium Complexes: Synthesis and Chiroptical Properties. Angew. Chem. Int. Ed. 2023, 62, e202212770.

23. Wang, X.;^§ Zheng, Y.;^§ Han, M.; Zhang, H.; Duan, Z.; Shao, M.; Jia, J.; Lei, C.* 1,4-Phenylene incorporated decaphyrin tetrarhodium(I) complex: synthesis, structures and chiroptical properties. J. Porphyr. Phthalocya. 2023, 27, 1059-1066.

24. Chen, H.;^§ Lei, Y.;^§ Xu, Y.; Shao, M.; Duan, Z.; Lei, C.* Phenanthrene-Incorporated Isoamethyrin: A Near-Planar Macrocycle That Display Enhanced Aromaticity via Protonation-Triggered Conformation Changes. J. Org. Chem. 2023, 88, 11352-11357.

25. Han, P.; Han, M.; Sessler, J. L.;* Lei, C.* Resolution of Expanded Porphyrinoids: A Path to Persistent Chirality and Appealing Chiroptical Properties. Chem.-Eur. J. 2023, 29, e202303058.

【荣誉获奖】

2023    上海大学理学院优秀研究生导师

2022    上海大学嘉奖

2021    上海大学理学院科研贡献奖

2020    上海大学理学院科研贡献奖

2020    上海市“青年科技启明星”

2018     上海市高校特聘教授（东方学者）

2012    中科院化学所青年科学优秀奖，中科院化学所“凯莱英”研究生系列报告优秀报告

2008    北京市优秀毕业生，北京师范大学优秀毕业生，北京师范大学优秀毕业论文